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古新梅 Hsin-Mei Ku - 教授
古新梅 Hsin-Mei Ku 教授
專任教師
遺傳育種組
04-22840777#705
hmku@email.nchu.edu.tw; ORCID https://orcid.org/0000-0002-8952-1923
植物分子遺傳、育種，植物基因編輯、分子標誌開發與應用、植物抗病機制、植
物生物技術。
研究室 pdf

學歷

博士學位: 美國康乃爾大學植物系
學士學位: 國立中興大學植物病理學系

經歷 / 榮譽

現職:教授, 國立中興大學農藝系
博士後研究員:美國康乃爾大學植物育種系
助理教授、副教授、教授

學術著作

1. Jing-Han Chen, Hsin-Mei Ku, Ho-Hsiung Chang, Chung-Jan Chang, Fuh-Jyh Jan *
(2026) Identification and characterization of maize yellow mosaic virus causing mosaic
symptoms on maize in Taiwan. Agriculture 16(1), 27;
https://doi.org/10.3390/agriculture1601002(accepted 2025 Dec. 16; online publication
2025 Dec 22)
2. Jui-Chieh Liu, Shang-Ling Ou, Hui-Ju Chang, Sheng-Wen Wang,Ping-Yen Chiu, Guan-
Ling Chen, Chien-Chi Huang, Chien-Hung Chung, Hsin-Mei Ku* (2026). Evaluation of
Tobacco Rattle Virus-based Vectors for Gene Silencing and Editing in Tomato. Journal of
the American Society for Horticultural Science, 151(1), 1–13.
https://doi.org/10.21273/JASHS05544-25 本人為通訊作者(2025, Nov, 7 接受;Online
Publication Date: 2025 Dec. 11).
3. Hui-Ju Chang, Hsin-Mei Ku* (2024) The Current Status and Prospects of Virus-Induced
Gene Editing in Plant. Agricultural Research & Technology, 28(5): 556427. 本人為通訊
作者(2024, Sep, 17).
4. Jen-Ren Chen and Hsin-Mei Ku* (2024)。Progress of Sex Determination in Papaya
(Carica papaya L.). Journal of Agriculture and Forestry,71(1):1-6
(10.30089/JAF.202403_71(1).0001) 本人為通訊作者 (2024, Jan)
5. 古新梅*。 2023。「分子標誌育種原理與技術介紹及應用」於專書「精準育種科技
之應用及發展。第一章精準育種技術之介紹及應用」。pp5-21。2023 年1 月。教育
部精準健康產業跨領域人才培育計畫精準農業教學推動中心出版。ISBN 978-986-
96453-6-2。
6. Yen-Hsiang Huang, Hsin-Mei Ku, Chong-An Wang, Ling-Yu Chen, Shan-Syue He, Shu
Chen, Po-Chun Liao, Pin-Yuan Juan, Chung-Feng Kao* (2022) A multiple phenotype
imputation method for genetic diversity and core collection in Taiwanese vegetable
soybean. Front Plant Sci . 13: 948349. (SCI)
7. Jen-Ren Chen, Hiroki Ueno, Hideo Matsumura, Naoya Urasaki, Chen-Yu Lee, Fure-Chyi
Chen, Shih-Wen Chin, Chun-Chi Liu, Chan-Tai Chiu, Kazuhiko Tarora, Jing-Yi Li, Chieh
Ying Lee, and Hsin-Mei Ku* (2021) Genomic characterization of a rare Carica papaya X
chromosome mutant reveals a candidate monodehydroascorbate reductase 4 gene
involved in all-hermaphrodite phenomenon. Mol Gen Genet 296, 1323-1335 (SCI)
8. Jen-Ren Chen, Shang-Ling Ou, Ting-Iun Nieh, Chih-Yu Lu, Hsin-Mei Ku* (2020)
Molecular dissection of Cucumis metuliferus resistance against Papaya ringspot virus by
grafting. Plants 9, 1666 (SCI)
9. Shu-Yun Chen, Mei-Hsiu Su, Karl A. Kremling, Nicholas K. Lepak, M. Cinta Romay, Qi
Sun, Peter J. Bradbury, Edward S. Buckler and Hsin-Mei Ku* (2020) Identification of
miRNA-eQTLs in Maize Mature Leaf by GWAS. BMC Genomics 21:689 (SCI)
10. Lee, C.-H., Zheng, Y.-X., Chan, C.-H., Ku, H.-M., Chang. C.-J., and Jan, Fuh-Jyh*.
(2020). A single amino acid substitution in the movement protein enables the mechanical
transmission of a geminivirus. Molecular Plant Pathology: 21:571-588 (SCI)
11. 古新梅*。蔬菜作物分子育種之概論2020 年2 月。前瞻基因體學技術於農業領域之
研發應用與展望。pp27-42。台大動植物農業產業窗新教育推動中心。ISBN 978-
986-5452-17-9。
12. Jen-Ren Chen, Naoya Urasaki, Hideo Matsumura, I-Cheng Chen, Mei-Jiuan Lee, Hui-Ju
Chang, Wen-Chuan Chung and Hsin-Mei Ku＊（2019） Dissecting the allhermaphrodite
phenomenon of a rare X chromosome mutant in papaya (Carica papaya
L.). Mol Breed 39(1): 14 (SCI)
13. Jen-Ren Chen, Shu-Hui Chen, Ju-Ling Lin and Hsin-Mei Ku* (2018) Advanced
methylation-sensitivity amplified polymorphism analysis. Seed and Nursery (Taiwan)
18(2): 27-46
14. Wei-Ting Liu, Peng-Wen Chen, Li-Chi Chen, Chia-Chun Yang, Shu-Yun Chen, GuanFu
Huang, Tzu-Che Lin, Hsin-Mei Ku* and Jeremy J.W. Chen* (2017) Suppressive Effect of
MicroRNA319 Expression on Rice Plant Height. Theor Appl Genet 130(7):1507-1518
(SCI )
15. 古新梅*。王肇芬。 2015。分子輔助抗病育種 。種苗產業發展新趨勢研討會專
刊。行政院台南區農業改良場出版。20151127。
16. Chia-Wei Lin, Mei-Hsiu Su, Yu-Tsung Lin, Chien-Hung Chung and Hsin-Mei Ku* (2015)
Functional Characterization of Cucumis metuliferus Proteinase Inhibitor Gene (CmSPI)
in Potyviruses Resistance. Viruses 7: 3816-3834; (SCI )
17. Chia-Wei Lin, Yi-Hua Lin, Yu-Tsung Lin, Wei-Chien Chen, Chien-Teh Chen, Shang-Ling
Ou and Hsin-Mei Ku* (2014) Investigation of transgenic tobacco salt and drought
tolerance in overexpression of horned melon serine proteinase inhibitor gene in tobacco
plants. Crop Environment and Bioinformatics 11(4)
18. Chao-Chin Huang, Shang-Ling Ou, Chong-Zheng Lin, Sz-Yun Chen, Ju-Chieh Chou and
Hsin-Mei Ku* (2014) Simulation study of genomic markers for Zucchini yellow mosaic
virus Resistance in Winter Squash (Cucurbita moschata). Crop Environment and
Bioinformatics 11: 26-38
19. Mulyantoro, Shang-Ling Ou, Shu-Yun Chen, Szu-Chien Liu, Tzu-Chuan Lo, Andi
Wahyono, Sz-Yun Chen and Hsin-Mei Ku* (2014) Conversion of genic male sterility
(GMS) system of bell pepper (Capsicum annuum L.) to cytoplasmic male sterility (CMS).
Plant Breeding 133(2):291-297 (SCI )
20. Jo-Chu Chen, Yen-Chu Wang, Hsin-Pang Tsai, Shyh-Shyan Wang, Hung-Wei Wang, and
Hsin-Mei Ku1* (2013) Molecular Genetic Characterization of Fruit Firmness and
Thickness Loci in Tomato. J. Taiwan Soc. Hort. Sci. 59(3):219-229, 201
21. Yu-Tsung Lin, Fuh-Jyh Jan, Chia-Wei Lin, Tzu-Chuan Lo, Chien-Hung Chung, Jo-Chu
Chen, Hsiang-Hao Su, Shy-Dong Yeh, and Hsin-Mei Ku* (2013) Differential Gene
Expression in Response to Papaya ringspot virus Infection in Cucumis metuliferus using
cDNA- Amplified Fragment Length Polymorphism Analysis. PLOSONE 8(7) e68749
July(SCI )
22. Shu-Yun Chen, Ting-Xuan Dai, Yuan-Tsung Chang, Shyh-Shyan Wang, Shang-Ling Ou,
Wen-Ling Chuang, Chih-Yun Cheng, Yi-Hua Lin, Li-Yin Lin and Hsin-Mei Ku* (2013)
Genetic diversity among Ocimum species based on ISSR, RAPD and SRAP markers.
Austral J Crop Sci 7(10): 1463- 1471
23. Huei-Mei Chen, Hsin-Mei Ku, Roland Schafleitner, Tejinderjit S. Bains, C. George Kuo,
Chien-An Liu, and Ramakrishnan M. Nair (2013) The major Quantitative Trait Locus for
Mungbean yellow mosaic Indian virus resistance is tightly linked in repulsion phase to the
major bruchid resistance locus in a cross between mungbean [Vigna radiata (L.) Wilczek]
and its wild relative Vigna radiata ssp. Sublobata. Euphytica 192: 205-216 (SCI )
24. Kuang‐Ming Hsu, Jinn‐Lai Tsai, Ming‐Yih Chen, Hsin‐Mei Ku*, Szu‐Chien Liu* (2013)
Molecular phylogeny of Dioscorea in East and Southeast Asia. Blumea - Biodiversity,
Evolution and Biogeography of Plants, 58 (1): 21-27 (SCI )
25. Ching-Yi Lin, Hsin-Mei Ku, Yi-Hua Chiang, Hsiu-Yin Ho, Tsong-Ann Yu,and Jan, Fuh-
Jyh*. (2012) Development of transgenic watermelon resistant to Cucumber mosaic virus
and Watermelon mosaic virus by using a single chimeric transgene construct Transgenic
Res : 21: 983-993*The authors Ching-Yi Lin and Hsin-Mei Ku equally contributed to this
work. (SCI)
26. Hsin-Mei Ku, Chee-Wee Tan, Yen-Shuo Su, Chih-Yu Chiu, Chien-Teh Chen*, and Fuh-
Jyh Jan* (2012) The effect of water deficienct and excess copper on proline metabolism
in Nicotiana benthamiana. Biologia Plantarum 56(2): 337-343 (SCI )
27. Lin, C.-Y., Tsai, W.-S., Ku, Hsin-Mei, and Jan, Fuh-Jyh* (2012) Evaluation of DNA
fragments covering the entire genome of a monopartite begomovirus for induction of viral
resistance in transgenic plants via gene silencing. Transgenic Res 21(2): 231-241(SCI)
28. Hsin-Mei Ku, Chi-Chien Hu, Hui-Ju Chang, Fuh-Jyh Jan* and Chien-Teh Chen*(2011)
Analysis by virus induced gene silencing of the expression of two proline biosynthetic
pathway genes in Nicotiana benthamiana under stress condition. Plant Physiol &
Biochem 49(10): 1147-1154 (SCI )
29. Yu-Tsung Lin, Chia-Wei Lin, Chien-Hung Chung, Mei-Hsiu Su, Hsiu-Yin Ho, Shi-Dong
Yeh, Fuh-Jyh Jan*, and Hsin-Mei Ku* (2011) In Vitro Regeneration and Genetic
Transformation of Cucumis metuliferus via Cotyledon Organogenesis. HortScience 46(4):
616-621 (SCI)
30. Ching-Yi LIN, Hsin-Mei KU, Chee-Wee TAN, Shyi-Dong YEH and Fuh-Jyh JAN (2011).
Construction of the binary vector with bi-selectable markers for generating marker-free
transgenic plants. Bot Stud, 52: 239-248(SCI)
31. Li, Charng-Pei, Huang Shou-Horng, Chen Jen-Ren, Tseng Tung-Hi, Lai Ming-Hsing and
Hsin-Mei Ku* (2011) Molecular characterization of introgression lines from a wild rice,
Oryza officinalis, with resistance to brown planthopper. J. Taiwan Agric. Res. 60: 263-278
32. Lin, Ching-Yi, Ku, Hsin-Mei, Tsai Wen-Shi, Green Sylvia K., and Jan, Fuh-Jyh (2011)
Resistance to a DNA and a RNA virus in transgenic plants by using a single chimeric
transgene construct. Transgenic Res. 20(2):261-270. (SCI)
33. Zhong-Bin Wu, Hsin-Mei Ku, Chiou-Chu Su, Iou-Zen Chen and Fuh-Jyh Jan* (2011)
Molecular and biological characterization of an isolate of Apple stem pitting virus causing
pear vein yellows disease in Taiwan. Journal of Plant Pathology 92:723-730. (SCI)
34. Shu-Yun Chen, Yu-Tsung Lin, Chia-Wei Lin, Wei-Yu Chen, Chih-Hung Yang, and Hsin-
Mei Ku* (2010) Transferability of rice SSR markers to bamboo. Euphytica 175: 23-33
(SCI).
35. Wu, Zhong-Bin, Ku, Hsin-Mei, Chen, Yun-Kun, Chang Chung-Jan and Jan, Fuh-Jyh*.
(2010). Biological and molecular characterization of Apple chlorotic leaf spot virus
causing chlorotic leaf spot on pear (Pyrus pyrifolia) in Taiwan. HortScience 45: 1073-
1078 (SCI )
36. Jen-Ren Chen, Hsin-Mei Ku, Jau-Yeuh Wang, and Min-Tze Wu. (2010). Exploitation and
Characterization of EST-Derived Microsatellite Markers in Watermelon [Citrullus lanatus
(Thunb.) Matsum & Nakai]. J. Taiwan Agric. Res. 58(4)310-315.
37. Chang, Ho-Hsiung, Ku, Hsin-Mei, Tsai, Wen-Shi, Chien Rui-Che, and Jan, Fuh-Jyh*.
(2010) Identification and characterization of a mechanical transmissible begomovirus
causing leaf curl on oriental melon. European Journal of Plant Pathology 127:219-228
(SCI )
38. Charn-Pei Li, Hsin-Mei Ku, Tzer-Kuan Hui, Chyr-Guan Chern, Ming-Hsing Lai, Ching-
Shan Tseng, Jen-Ren Chen, and Tung-Hi Tseng. (2009) Construction of Intregression
Lines from Wild Rice (Oryza australiensis Domin) and Assessment of Yield-Related
Traits. J. Taiwan Agric. Res. 58:219-233.
39. Mulyantoro, Shu-Yun Chen, Andi Wahyono, and Hsin-Mei Ku* (2009) Modified
complementation test of male sterility mutants in pepper (Capsicum annuum L.):
preliminary study to convert male sterility system from GMS to CMS. Euphytica 169:
353-361( SCI).
40. Shen, B.-N., Zheng, Y. X., Chen, W. H., Chang, T. Y., Ku, Hsin-Mei, and Jan, Fuh-Jyh *
(2009). Occurrence and molecular characterization of three pineapple mealybug wiltassociated
viruses in pineapple in Taiwan. Plant Disease 93:196 (SCI)
41. Chang, H.-H., Ku, H.-M., and Jan, Fuh-Jyh*. (2009). Current progress and prospect of the
reverse genetics of negative-strand RNA viruses. Plant Pathology Bulletin 18:201-216
42. Chang, H.-H., Tseng, H.-H., Yeh, S.-D., Ku, H.-M.* and Jan, Fuh-Jyh*. (2009).
Generation of monoclonal antibody against the replicase of Watermelon silver mottle
virus and its application on the detection of L protein expression in planta. Plant
Pathology Bulletin 18: 237-246.
43. Lin, C.-Y., Tsai, W.-S., Ku, H.-M.*, and Jan, Fuh-Jyh*. (2009) Transgenic strategies for
developing transgenic plants with geminivirus resistance. Plant Pathology Bulletin
18:185-200.
44. Huei-Mei Chen, Chien-An Liu, C. George Kuo, Ching-Mei Chien, Horng-Chi Sun,
Chunh-Chu Huang, Yu-Chung Lin and Hsin-Mei Ku * (2007) Development of a
molecular marker for a bruchid (Callosobruchus chinensis L.) resistance gene in
mungbean. Euphytica 157: 113-122. (SCI)
45. Chong-Zheng Lin, Chang-Pei Li, Shu-Yun Cheng, Yu-Chung Lin, Ai-Na Hsu, Fu-Sheng
Thseng, Shu-Tu Wu and Hsin-Mei Ku* (2007) Tagging QTL for Grain Quality Related
Traits by Rice SSR Markers. Crop Environment and Bioinformatics 4: 269-284.
46. Meng-Huei Lin, Chia-Wei Lin, Jo-Chu Chen, Yu-Chung Lin, Shu-Yun Cheng, Tzung-Hua
Liu, Fuh-Jyh Jan, Shu-Tu Wu, Fu-Sheng Thseng and Hsin-Mei Ku* (2007 ) Tagging Rice
Drought-related QTL with SSR DNA Markers. Crop Environment and Bioinformatics
4(1): 65-76.
47. Doganlar S., Frary A., Hsin-Mei Ku, and S. D. Tanksley (2002) Mapping Quantitative
Trait Loci in Inbred Backcross Lines of Lycopersicon pimpinellifolium (LA1589)
Genome 45:1189-202. (SCI)
48. Jan, Fuh-Jyh and Ku, H.-M. (2001). Development of transgenic plants resistant to
multiple viruses via gene silencing. Pages 239-250 in Proceedings of International
Symposium on Biological Control of Plant Diseases for the New Century-Mode of Action
and Application Technology. D. S. Tzeng and J. W. Huang, eds., Department of Plant
Pathology, National Chung Hsing Univereisty Press, Taichung, Taiwan.
49. Ku Hsin-Mei, Liu J.P., Doganlar S., and Tanksley S. D. (2001) Exploitation of
Arabidopsis-Tomato synteny to construct a high-resolution map of the ovate locus in
tomato chromosome 2. Genome 44: 470-475. (SCI)
50. Ku Hsin-Mei, Vision T., Liu J. and Tanksley S. D. (2000) Comparing segments of the
tomato and Arabidopsis genomes: Large-scale duplication followed by selective gene loss
creates a network of synteny. Proc. Natl. Acad. Sci. USA 97(16): 9121-9126. (SCI)
51. Ku Hsin-Mei, S. Grandillo and S. D. Tanksley (2000) A major QTL, fs8.1, setting the
pattern of tomato carpel shape well before anthesis. Theor. Appl. Genet. 101:873-878
(SCI)
52. Ku Hsin-Mei, S. Doganlar, K.-Y. Chen and S. D. Tanksley (1999) The genetic basis of
pear-shaped tomato fruit. Theor. Appl. Genet. 99(5): 844-850 (SCI)
53. Grandillo S, Hsin-Mei Ku, S. D. Tanksley (1999) Identifying the loci responsible for
natural variation in fruit size and shape in tomato. Theor. Appl. Genet. 99(6): 978-98.
(SCI)
54. Ku Hsin-Mei, and S. D. Tanksley (1998) Round fruit allele of fs8.1 is associated with
reduced incidence of blossom-end rot in tomato fruit. Tomato Genet. Coop. Report 48:
28-29.
55. Grandillo S, Hsin-Mei Ku, S. D. Tanksley (1996) Characterization of fs8.1, a major QTL
influencing fruit shape in tomato. Molecular Breeding 2: 251-260. (SCI)
56. Ku, H. M. and H. S. Tsay. (1994). Effects of medium composition on the vitrification of
carnation seedlings culture in vitro. Jour. Agric. Res. China 43:51-62.
57. Ku, H. M. and H. S. Tsay. (1994). Influence of subculture generation on the vitrification
of carnation plantlets culture in vitro. Jour. Agric. Res. China 43:308-319.
Dissertation
Ku Hsin-Mei (1998) Ph. D. Department of Plant Biology, Cornell University, Ithaca, USA.
Dissertation: “Toward map-based cloning of fruit shape QTLs: a major QTL setting the
pattern of carpel shape well before anthesis; genetic characterization and molecular mapping,
high-resolution genetic and physical mapping of a major locus controlling pear-shaped fruit in
tomato”.

 
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